[Arg3] Substance P is a synthetic analog of the endogenous neuropeptide Substance P, featuring an arginine substitution at the third amino acid position (Arg3) within its 11-amino acid sequence. As a member of the tachykinin family, native Substance P binds to neurokinin 1 (NK1) receptors, regulating processes like pain transmission, inflammation, and immune cell activation. The Arg3 modification in this analog is designed to alter its binding affinity, stability, or signaling efficacy at NK1 receptors, potentially enhancing resistance to proteolytic degradation or modulating receptor-mediated responses. In research, [Arg3] Substance P is used to investigate the structural determinants of NK1 receptor interactions, explore its role in pain pathways, neuroinflammation, and respiratory function, or serve as a lead compound for developing more potent or selective NK1 receptor agonists/antagonists. By modifying specific amino acid residues, such analogs help elucidate the molecular mechanisms of Substance P and inform the design of therapeutic agents targeting NK1 receptor-related disorders, including chronic pain, depression, or inflammatory diseases.

Chemical Formula: C63H98N20O13S

Molecular Weight: 1375.67

Sequence: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Purity: From crude to 98%

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